Selling your real estate is somewhat like seeking a short term business partner. The same attributes you want to see in a business partner: courageous, able, prepared, committed, are what you want in buyer partner. So it makes sense that red flags indicating fear, unprepared, uncertain, marginal ability, and lack luster commitment would cause hesitation. Both people could be very good friends, but only one is likely to be a responsible business partner.
What do the terms of your Offer to Purchase tell the Seller about you? Potential partner or friend? Customize your offer. The business partner would.